KLHL: A Potential Drug Target Or Biomarker (P48413)

Target Name: Kelch-like protein

NCBI ID: P48413

Kelch-like protein

Other Name(s): KLHL

KLHL: A Potential Drug Target Or Biomarker

Kelch-like protein (KLHL) is a protein that is expressed in various tissues throughout the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the Kelch family of proteins, which are characterized by the presence of a unique domain called the N-terminal alpha-helix. While KLHL is not a well-studied protein in isolation, its function and potential as a drug target or biomarker is of interest to researchers.

The Kelch family of proteins was identified in the 1970s by researchers who found that many organisms, including humans, contain proteins with a similar domain structure. These proteins are now known as Kelch-like proteins (KLPLs) or N-terminal alpha-helical proteins (NTAPs). KLPLs are characterized by the presence of a unique domain that is composed of multiple amino acids that form a alpha-helical structure. This domain is responsible for the unique structural features of KLPLs and gives them their name.

KLHL is a member of the KLPL family and is expressed in various tissues throughout the body. It is highly conserved, with significant sequence identity to other KLPLs, such as KLPL-1 and KLPL-2. KLHL is found in a variety of cellular organelles , including the nucleus, mitochondria, endoplasmic reticulum, and the cytosol. It is also expressed in various cell types, including epithelial cells, muscle cells, and neural cells.

One of the unique features of KLHL is its ability to form a stable complex with other proteins. This is accomplished through the presence of a unique N-terminal domain that is involved in protein-protein interactions. KLHL contains a variety of different domains that are involved in these interactions, including a short amino acid loop, a long amino acid loop, and a variable region. The N-terminal domain of KLHL is also known as the \"helix-turn-helix\" domain and is responsible for the formation of the alpha-helical structure that is characteristic of KLPLs.

In addition to its structural features, KLHL is also known for its role in various cellular processes. For example, KLHL has been shown to play a role in the regulation of cytoskeletal organization and stability. It has also been shown to be involved in the regulation of cell adhesion and in the development of various diseases, such as cancer.

As a potential drug target, KLHL is of interest to researchers because of its unique structure and function. The alpha-helical structure of KLHL makes it a potential target for small molecules that can modulate its activity. Additionally, because KLHL is expressed in a variety of cellular organelles and cell types, it is a potential biomarker for a variety of diseases.

While KLHL is not yet a well-studied protein in isolation, research into its function and potential as a drug target or biomarker is ongoing. For example, researchers have shown that KLHL can be targeted by small molecules and that its activity can be modulated by these molecules. Additionally, researchers have used KLHL as a biomarker to study a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In conclusion, Kelch-like protein (KLHL) is a protein that is characterized by its unique alpha-helical structure and its ability to form stable complex with other proteins. While KLHL is not yet a well-studied protein in isolation, its unique structure and function make it of interest as a potential drug target or biomarker. Further research is needed to fully understand the role of KLHL in various cellular processes and its potential as a therapeutic agent.

Protein Name: Kelch-like Protein (nonspecified Subtype)

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•   expression level;
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